The Heparan Sulfate Binding Sequence of Interferon-γ Increased the On Rate of the Interferon-γ-Interferon-γ Receptor Complex Formation
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چکیده
منابع مشابه
Increasing Affinity of Interferon-γ Receptor 1 to Interferon-γ by Computer-Aided Design
We describe a computer-based protocol to design protein mutations increasing binding affinity between ligand and its receptor. The method was applied to mutate interferon-γ receptor 1 (IFN-γ-Rx) to increase its affinity to natural ligand IFN-γ, protein important for innate immunity. We analyzed all four available crystal structures of the IFN-γ-Rx/IFN-γ complex to identify 40 receptor residues ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.18.10919